The ERG responses and histopathological findings of mice retina exposed to constant light stimulation
| A | Genotype | Score | Total | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | |||||||
| Transgenic | 7 | 3 | 4 | 14 | |||||
| Littermate | 0 | 4 | 9 | 13 | |||||
| Score | |||||||||
| B | Genotype | 0 | 1 | 2 | 3 | Total | |||
| Transgenic | 4 | 4 | 2 | 4 | 14 | ||||
| Littermate | 0 | 1 | 7 | 5 | 13 | ||||
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The ERG responses and histopathological findings were scored by three observers blinded to the EAT genotype for the degree of potential rescue. Definition of the scores are described in the Materials and methods section. (A) The mean score (SD) of the ERG response of EAT transgenic mice (0.79 (0.89)) was significantly lower than that of the littermates (1.69 (0.48), p = 0.0074). (B) The mean scores (SD) of the histopathological findings of the littermates (2.31 (0.63)) versus EAT transgenic mice (1.43 (1.22)) were not significantly different (p = 0.065).
