Table 1
Summary of possible pharmacological ways to attenuate ganglion cell destruction as suggested in Figures 2and 3
| • Counteract risk factor in question—eg, lower raised IOP |
| • Maintain normal blood supply to optic nerve head |
| • Prevent hypoxic/oligaemic insult to ganglion cell axons |
| • Prevent substance release from astrocytes/microglia that may affect ganglion cell survival |
| • Maintain optimum functioning of Müller cells |
| • Prevent glutamate toxicity to retinal neurons |
| • Prevent excessive depolarisation of ganglion cells |
| • Administration of neurotrophic factors |
