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Br J Ophthalmol 2001;85:1313-1315 doi:10.1136/bjo.85.11.1313
  • Scientific correspondence

Plasma homocysteine, methylene tetrahydrofolate reductase C677T and factor II G20210A polymorphisms, factor VIII, and VWF in central retinal vein occlusion

  1. S Boyda,
  2. D Owensb,
  3. T Gina,
  4. K Buncec,
  5. H Sherafata,
  6. D Perryb,
  7. P G Hykina
  1. aMoorfields Eye Hospital, City Road, London EC1V 2PD, UK, bThe Haemophilia Centre and Haemostasis Unit, Department of Haematology, The Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK, cDepartment of Epidemiology, Moorfields Eye Hospital, City Road, London EC1V 2PD, UK
  1. Mr Philip G Hykin, Moorfields Eye Hospital, City Road, London EC1V 2PD, UK philhykin{at}aol.com
  • Accepted 16 May 2001

Abstract

AIMS To determine whether plasma homocysteine, methylene tetrahydrofolate reductase (MTHFR) C677T and factor II G20210A polymorphisms, factor VIII, and vWF are risk factors for central retinal vein occlusion (CRVO).

METHOD Prospective comparison of 63 consecutive patients with central retinal vein occlusion and 63 age matched controls. Plasma homocysteine and vWF were estimated by ELISA, the MTFHR and factor II G20210A polymorphisms determined by polymerase chain reaction with restriction enzyme product digestion and factor VIII by one stage automated clotting assay.

RESULTS Plasma homocysteine (patients: median 12.4 μmol/l, controls: median 11.6 μmol OR = 1.05, p=0.20), factor VIII (patients: median = 115 U/dl, controls: median = 113 U/dl), and vWF (patients: median = 115 U/dl, controls: median = 108 U/dl) were not statistically higher in patients than in controls. Five CRVO patients and seven controls were homozygous for the MTHFR C677T mutation. One control was heterozygous for the factor II G20210A mutation.

CONCLUSION This study has not identified new risk factors for CRVO.

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