Article Text

PDF

Blinding trachoma: the forgotten problem
  1. KHALID F TABBARA
  1. The Eye Center and The Eye Foundation for Research in Ophthalmology, Riyadh, Saudi Arabia
  1. The Eye Center, PO Box 55307, Riyadh 11534, Saudi Arabia k.tabbara{at}nesma.net.sa

Statistics from Altmetric.com

The 20th century has witnessed great economic, scientific, and technological progress. We have lived in an era of great biotechnological achievements. Our diagnostic and therapeutic abilities in the management of infectious diseases have improved dramatically. Some infections such as smallpox have been eradicated by vaccination, others have been controlled by vigorous public health measures. The resilience of viruses and the tenacity of bacteria have led to the emergence of new infectious diseases and the evolution of old ones. Microbe hunters have won many battles against infections in the 20th century, but the war against classic and emerging infectious diseases is not over. Many new viruses have been discovered over the past two decades including HIV. The degradation of the ecological system, destruction of rain forests, overcrowding and the population boom are exposing humankind to new forms of infectious diseases. With air travel, the world is becoming a true global village and geographic barriers are being disrupted. An infectious agent may jump from the jungles of Africa to the urban communities of the Western hemisphere in a few hours. West Nile virus was recently reported in New York and other eastern states. It is our responsibility to stimulate, encourage, and intensify a continued concerted effort to establish an assault on new and old causes of infectious diseases that may lead to blindness with the ultimate goal of developing new ways to diagnose, new ways to treat, and means to prevent blinding and fatal infections. After the second world war there was a widespread of optimism in the United States that good sanitation, vaccines, and antibiotics would conquer all infectious diseases. This elation and euphoria were of short duration. The control of classic infections was followed by epidemics of infectious diseases. The emergence of new infectious diseases such as AIDS and Ebola virus, and the evolution of old ones such as tuberculosis are becoming serious health problems and important cause of morbidity and mortality. None the less, there has been a dramatic decrease in the incidence of classic infectious diseases over the past four to five decades—a development that can be largely attributed to public health measures, mass vaccination, and the use of new generations of antibiotics.

Trachoma has been recognised since antiquity, and ironically the first effective therapeutic modality using copper sulphate sticks was described by the early Egyptians thousands of years ago, yet trachoma remains a leading cause of blindness in the 21st century in rural Egypt. Currently, the disease afflicts 500 million people and is considered to be among the most common of all human chronic infections, and the most common cause of preventable blindness today. Yet no serious preventive measures or organised campaigns have been conducted in trachoma endemic areas. Active trachoma is seen among people in low socioeconomic groups and appears to be common in underdeveloped and developing countries. It is frequently observed among children who form a large reservoir of the intracellular agent.

With the beginning of the 21st century, despite Western technology and advances in the field of medicine, trachoma remains a serious health problem leading to ocular morbidity and blindness in many underdeveloped and developing countries, including eastern Mediterranean countries.1 In this issue of theBJO, (p 1406) Ezz al Arab and associates have shown that trachoma is a serious health problem in one rural community in Egypt, and remains a major cause of preventable blindness in rural Egypt. Despite the overall socioeconomic development, active trachoma was found among 36.5% of the children. Severe active trachoma was more common among rural children than urban children. In addition, cicatrising trachoma led to blindness in 8% of the adult population and accounted for visual impairment in 13% of the survey members. This means that one out of five individuals above the age of 50 years in one rural community of Egypt suffer from visual loss because of trachoma. This makes trachoma the most important preventable cause of blindness in rural communities of Egypt. This survey underscores the seriousness of trachoma in many developing countries where the health authorities have assumed a less aggressive role in the screening, treatment, and prevention of blindness from trachoma. Medical equipment and pharmaceutical companies have been marketing sophisticated technology and new therapeutic agents to developing nations. In certain country, emphasis on the use of new technology and instruments has been placed ahead of simple treatment of blinding infections such as trachoma that can be treated and controlled by simple inexpensive means. Failure of surgical correction of trichiasis was also noted by Ezz al Arabet al, which points out the importance of continuing medical education and training of health workers for early detection and treatment of trachoma and the management of entropion and trichiasis. Requirements for improving eye care and prevention of blindness from trachoma have been previously outlined.1Other studies have shown the persistence of trachoma as an important cause of blindness in eastern Mediterranean countries.1 2Prevention of blindness from trachoma may cost less than US$1 per patient, but the treatment of the complications of the disease such as correction of entropion and trichiasis, dacryocystorhinostomy, and corneal transplantation may cost thousands of dollars. Governmental authorities have ignored insidious non-alarming chronic infections and focused on more conspicuous public health and epidemiological problems such as infant diarrhoea, tuberculosis, and mass vaccination for rubella, diphtheria, measles, and mumps. A realistic approach is to utilise existing primary healthcare centres and resources and to initiate public education and well organised nationwide campaigns for prevention and treatment of trachoma and its complications in rural areas. Continuing medical education programmes for nurses and general practitioners should be established to help in the recognition and treatment of blinding eye diseases.

The clinical and laboratory diagnosis of trachoma is simple. A single oral dose of azithromycin can be safe and effective in the treatment of active trachoma. Surgical correction of entropion and trichiasis is a simple procedure that may lead to the prevention of corneal ulceration, scarring, and blindness. The control of trachoma and its complications can be made available by simple, inexpensive means. This fact should be conveyed to the health authorities in developing countries. The Vision 2020 programme of the World Health Organization (WHO) and the International Agency for the Prevention of Blindness (IAPB) for the elimination of avoidable blindness by the year 2020 will have to place trachoma on the high priority list for the prevention of blindness in developing countries.3 4 Public education for personal hygiene, improving housing conditions, availability of potable water, early detection and treatment of active trachoma, and management of complications of trachoma, such as nasolacrimal duct obstruction, dry eyes, entropion, and trichiasis, can have a major impact on blindness caused by trachoma.

Despite advances in the field of medicine, classic infections such as trachoma remain unconquered major problems in developing countries. Unlike AIDS, trachoma is a curable disease, but control of trachoma is not just a medical problem. Control measures often fail not because of deficiencies in scientific knowledge or public health awareness but because of lack of commitment, lack of resources, political turmoil, and poor socioeconomic policies. In Egypt, as in other developing countries, there have been no recent official governmental programmes for the prevention and treatment of trachoma. Unlike tuberculosis where several strains of Mycobacterium tuberculosis have been identified to be resistant to several antibiotics, new resistant mutants of chlamydia have not been identified. Antimicrobial therapy remains an effective treatment for active trachoma.

Economic development appears to help in decreasing the prevalence and the severity of the disease, but in the study reported by Ezz al Arab and associates, the socioeconomic development did not appear to decrease the prevalence or the severity of trachoma. In a nationwide survey of trachoma in Saudi Arabia, evidence of active or inactive trachoma was found among 22% of Saudi individuals and 6% had evidence of active trachoma.2 In addition, 17% of survey members had conjunctival scarring as a result of old trachoma and 1.5% had entropion and trichiasis. Ten years later, with the socioeconomic development in Saudi Arabia, the prevalence of trachoma decreased to 11% of the Saudi population, while 2.6% had active trachoma, suggesting that in one decade there was a dramatic decrease in the prevalence of trachoma and its complications. The prevalence of trachoma in households was directly related in the presence and appearance rating of children in the household, the presence of flies, and the appearance rating of the household itself.2 This study showed a decrease in the prevalence of active trachoma in a short period of time in another eastern Mediterranean country, but trachoma prevention and treatment campaigns are urgently needed.

Trachoma is a chronic inflammation that leads to spontaneous resolution accompanied by extensive cicatrisation of the conjunctiva and subconjunctival tissues leading to inward deviation of the eyelashes and lid margins. The trichiasis disrupts the anatomical integrity of the corneal epithelium leading to ulceration and causing opacification of the cornea. In most cases, active trachoma of the conjunctiva may heal without permanent visual loss, but in patients with chronic trachoma the disease may lead to serious damage of the ocular surface.1 Obstruction of the lacrimal ductules leads to tear deficiency, and cicatrisation of the conjunctiva leads to loss of goblet cells and mucus deficiency. Similar to trichiasis, dryness of the eye from trachoma may lead to disruption of the anatomical barriers of the corneal epithelium predisposing to secondary infections, corneal scarring, and blindness.

Attempts to prevent trachoma by immunisation with trachoma antigens have been conducted by various groups. The vaccine produced only short immunity to infection. A sensitised subject develops more serious ocular disease than an unimmunised control presumably as a result of the development of hypersensitivity induced by the vaccine. This sensitising effect of trachoma vaccine could be induced in monkeys with low dosage of the antigen and the hypersensitivity reaction is usually more severe than the protective effects of the vaccine. The sensitising effect afforded by the vaccination in contrast to protection was not just strain specific but also type specific. Such results have effectively blocked clinical trials in humans using the whole trachoma agent vaccine. To date there is no effective vaccine for trachoma. Identification of chlamydial antigens that afford protection against the infection without causing a hypersensitivity reaction are highly desirable. Vaccines are getting better and recent technological developments have made it possible to introduce recombinant DNA into mycobacteria such as BCG, the tuberculosis vaccine. It is, therefore, feasible to introduce foreign genes such as DNA or chlamydia and it would be possible to envisage the development of recombinant multiple vaccine vehicles in the future.

The active form of trachoma responds promptly to chemotherapy, but the aftermath of untreated disease will have to be addressed. In children the disease may be treated with topical tetracycline or erythromycin ointment twice daily or systemic erythromycin. Clinical response is slow but the greatest effect occurs in 3–4 months. One of the major problems we face in the treatment of active trachoma is lack of compliance since the majority of cases of active trachoma are asymptomatic. Assigning a 6 week treatment regimen for asymptomatic children may not be practical. Recent studies on azithromycin have shown that the drug is safe in the treatment of active trachoma. Several studies have shown that single dose azithromycin 20 mg/kg was as effective as topical tetracycline ointment in managing active trachoma.5 6 Single dose azithromycin, therefore, is effective and safe in the treatment of active trachoma; the treatment can establish high compliance and may contribute to the control of trachoma worldwide. In children, azithromycin may be given as a single 20 mg/kg dose per day and may be repeated in 1 month. Adults may be given 500 mg of azithromycin orally once daily for 3 days. and the regimen may be repeated in 1 month. The azithromycin levels were assessed in human serum aqueous, tear fluid, and conjunctival tissue specimens after the administration of single 1 g oral dose of azithromycin.7 Levels above the 90% minimal inhibitory concentration (MIC90) for Chlamydia trachomatis were found after 4 days in all samples and after 14 days in all conjunctival tissue specimens following oral azithromycin administration. The prolonged high concentration of azithromycin in conjunctival tissue makes this drug suitable for the treatment of conjunctivitis caused by chlamydia.

In conclusion, trachoma is a preventable and curable disease. Prevention of trachoma should be given top priority by the health authorities of countries with endemic trachoma. Mass treatment with azithromycin in schoolchildren such as in Al Menofiya in Egypt, where one out of three children are infected, may have to be considered. Public health education programmes should be initiated and trachoma control campaigns in countries with endemic trachoma should be started to meet the objective of “Vision 2020” of the WHO and the IAPB.

We cannot rest on the laurels we won for overcoming infections of the past, but we should be prepared for the battle of the 21st century against classic and emerging infectious diseases.

References

View Abstract

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles