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Br J Ophthalmol 85:461-470 doi:10.1136/bjo.85.4.461
  • Original Article
    • Laboratory science

Intravitreal invading cells contribute to vitreal cytokine milieu in proliferative vitreoretinopathy

Table 4

Relation between clinical variables and cytokine mRNA level normalised to HPRT

Clinical variable No Number of patients with detectable cytokine mRNA levels (%)
IL-6/HPRT IL-8/HPRT IL-1β/HPRT IFNγ/HPRT IL-1α/HPRT
Severity C1–C2 19 13 (68) 17 (89) 12 (63) 14 (87) 10 (52)
C3–D2 6 6 (100) 6 (100) 4 (66) 4 (80) 4 (66)
Duration 2–8 weeks 14 10 (71) 14 (100) 8 (57) 11 (84) 9 (64)
8–14 weeks 5 4 (80) 4 (80) 3 (60) 3 (75) 3 (60)
> 14 weeks 6 5 (83) 5 (83) 5 (83) 4 (100) 2 (33)
Recurrence No 14 9 (64) 12 (86) 7 (50) 10 (83) 6 (43)
Yes 11 10 (91) 11 (100) 9 (82) 8 (89) 8 (72)
No of previous surgeries 0 7 5 (71) 6 (86) 4 (57) 5 (100) 3 (43)
1 11 7 (63) 10 (91) 6 (54) 8 (80) 6 (55)
2–4 7 7 (100) 7 (100) 6 (86) 5 (83) 5 (71)
  • No = number of samples examined.

  • Number of samples investigated in each clinical group was slightly less than the examined number for other cytokines, due to insufficient sample.

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