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Br J Ophthalmol 2001;85:625 doi:10.1136/bjo.85.5.625g
  • Letter to the Editor

Surgical excision, autolimbal transplantation, and mitomycin C in the treatment of conjunctival and corneal intraepithelial neoplasia

  1. ANNIE JOSEPH,
  2. KOURESH SABRI,
  3. HARMINDER S DUA
  1. Department of Ophthalmology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK
  1. harminder.dua{at}nottingham.ac.uk
  • Accepted 24 January 2001

Editor,—Conjunctival and corneal intraepithelial neoplasia (CIN) are uncommon lesions of low malignant potential.1 Surgical excision is the standard treatment for this condition. However, owing to the poorly defined borders of these lesions, recurrence rates following surgical excision can be as high as 53%.2 Adjunctive therapy including cryotherapy,3 radiotherapy,4immunotherapy,5 and topical alcohol and urea have been used to treat the condition. Many of these procedures induce limbal stem cell failure with consequent corneal epithelial problems, requiring (auto) stem cell transplantation. Topical cytotoxic agents like 5-fluorouracil and mitomycin C have been used successfully in the treatment of CIN.6 However, inhibition of limbal stem cell division with mitomycin C is thought to notably impair physiological corneal epithelial replacement.7 We report the successful …

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