Ramosetron compared with granisetron for the prevention of vomiting following strabismus surgery in children
- aDepartment of Anaesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan, bDepartment of Ophthalmology
- Yoshitaka Fujii, Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, 2-1-1, Amakubo, Tsukuba City, Ibaraki 305-8576, Japanyfujii{at}igaku.md.tsukuba.ac.jp
- Accepted 26 January 2001
Abstract
BACKGROUND/AIMS Postoperative vomiting occurs frequently after strabismus surgery in children. Granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, is effective for the prevention of vomiting following paediatric strabismus surgery. Ramosetron, another new antagonist of 5-hydroxytryptamine type 3 receptor, has more potent and longer acting properties than granisetron against cisplatin induced emesis. This study was undertaken to compare the efficacy and safety of granisetron and ramosetron for the prevention of vomiting following strabismus surgery in children.
METHODS In a randomised, double blinded manner 80 children, aged 4–10 years, received intravenously granisetron 40 μg/kg or ramosetron 6 μg/kg (n=40 each) at the end of surgery. A standard general anaesthetic technique and postoperative analgesia were used. Emetic episodes and safety assessment were performed during the first 24 hours and the next 24 hours after anaesthesia.
RESULTS The percentage of patients who were emesis free during 0–24 hours after anaesthesia was 85% with granisetron and 90% with ramosetron, respectively (p = 0.369); the corresponding rate during 24–48 hours after anaesthesia was 70% and 95% (p = 0.003). No clinically serious adverse events caused by the study drug were observed in any of the groups.
CONCLUSION Prophylactic antiemetic therapy with ramosetron is comparable with granisetron for the prevention of vomiting during 0–24 hours after anaesthesia in children undergoing strabismus surgery. During 24–48 hours after anaesthesia, ramosetron is more effective than granisetron for prophylaxis against postoperative vomiting.
