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Br J Ophthalmol 2001;85:785-787 doi:10.1136/bjo.85.7.785
  • Scientific correspondence

Human papillomavirus in conjunctival papilloma

  1. Nicolai Christian Sjöa,
  2. Steffen Heegaarda,
  3. Jan Ulrik Prausea,b,
  4. Christian von Buchwaldc,
  5. Henning Lindebergd
  1. aEye Pathology Institute, University of Copenhagen, Denmark, bDepartment of Ophthalmology, Rigshospitalet, Denmark, cDepartment of Oto-rhino-laryngology, Rigshospitalet, Denmark, dOral Pathology Laboratory, Royal Dental College, University of Aarhus, Denmark
  1. Steffen Heegaard, Eye Pathology Institute, University of Copenhagen, Frederik V's Vej 11, DK-2100 Copenhagen, Denmarksh{at}eyepath.ku.dk
  • Accepted 26 January 2001

Abstract

AIM To examine conjunctival papillomas for the presence of human papillomavirus (HPV) and koilocytosis.

METHODS Archival paraffin embedded tissue from 55 conjunctival papillomas was analysed for the presence of HPV by polymerase chain reaction and subsequent filter hybridisation. Histological sections of the 55 papillomas were evaluated for the presence of koilocytosis.

RESULTS HPV was present in 48 of 52 (92%) β globin positive papillomas. HPV type 6/11 were found in 40 of 47 investigated papillomas and a double infection with HPV 6/11 and 16 was identified in a single papilloma. In six papillomas the HPV type could not be identified. Koilocytosis was present in 22 of 55 papillomas (40%).

CONCLUSION There is a strong association between HPV and conjunctival papillomas. HPV type 6/11 is the most common HPV type in conjunctival papilloma. The sensitivity of koilocytosis as an indicator of HPV in conjunctival papilloma is low.

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