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Original Article - Clinical science: Meta-analysis of randomised controlled trials comparing latanoprost with timolol in the treatment of patients with open angle glaucoma or ocular hypertension
  • W Y Zhang,
  • A Li Wan Po,
  • H S Dua,
  • A Azuara-Blanco
Br J Ophthalmol 2001;85:983-990 doi:10.1136/bjo.85.8.983

  1. Queries on latanaprost

    • Tariq Ansari
    Private practicing specialist
    Dear Editor

    The study is a good comparison of the two medications. I have a few queries for the authors:

    1) Why is latanoprost causing an increase in iris pigmentation; is that not a cause for concern and should this serious side effect not be investigated more fully?

    2) Latanoprost increases uveoscleral outflow; does it bypass the trabecular meshwork or is it causing any blockage in aqueous outflow from the angle of the anterior chamber? If such is the case, that an alternative pathway is being forced to function through drug stimulation, will that not cause a decrease or even a complete stoppage of the function of the normal outflow path?

    3) Patients develop drug resistance to beta-blockers after a period of time. Has Latanoprost been studied for this troublesome long-term side effect? Because I believe that any drug that is used for a lengthy period of time has a big chance of inducing drug resistance.

    Submit response
    Published 12 November 2001
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