rss
Original Article - Clinical science: Meta-analysis of randomised controlled trials comparing latanoprost with timolol in the treatment of patients with open angle glaucoma or ocular hypertension
  • W Y Zhang,
  • A Li Wan Po,
  • H S Dua,
  • A Azuara-Blanco
Br J Ophthalmol 2001;85:983-990 doi:10.1136/bjo.85.8.983

  1. Queries on latanaprost

    • Tariq Ansari
    Private practicing specialist
    Dear Editor

    The study is a good comparison of the two medications. I have a few queries for the authors:

    1) Why is latanoprost causing an increase in iris pigmentation; is that not a cause for concern and should this serious side effect not be investigated more fully?

    2) Latanoprost increases uveoscleral outflow; does it bypass the trabecular meshwork or is it causing any blockage in aqueous outflow from the angle of the anterior chamber? If such is the case, that an alternative pathway is being forced to function through drug stimulation, will that not cause a decrease or even a complete stoppage of the function of the normal outflow path?

    3) Patients develop drug resistance to beta-blockers after a period of time. Has Latanoprost been studied for this troublesome long-term side effect? Because I believe that any drug that is used for a lengthy period of time has a big chance of inducing drug resistance.

    Submit response
    Published 12 November 2001
« Parent article

Published letters

  1. Queries on latanaprost

Submit your response

This page

Register for free content

The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.