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Letter to the Editor
Electrophysiological abnormalities following intravitreal vitravene (ISIS 2922) in two patients with CMV retinitis
  1. H J ZAMBARAKJI,
  2. S M MITCHELL
  1. Department of Ophthalmology, Chelsea and Westminster Hospital, London, UK
  2. Department of Clinical Ophthalmology, Institute of Ophthalmology and Moorfields Eye Hospital, London, UK
  3. Department of Electrophysiology, Moorfields Eye Hospital, London, UK
  1. S LIGHTMAN
  1. Department of Ophthalmology, Chelsea and Westminster Hospital, London, UK
  2. Department of Clinical Ophthalmology, Institute of Ophthalmology and Moorfields Eye Hospital, London, UK
  3. Department of Electrophysiology, Moorfields Eye Hospital, London, UK
  1. G E HOLDER
  1. Department of Ophthalmology, Chelsea and Westminster Hospital, London, UK
  2. Department of Clinical Ophthalmology, Institute of Ophthalmology and Moorfields Eye Hospital, London, UK
  3. Department of Electrophysiology, Moorfields Eye Hospital, London, UK
  1. Dr Graham E Holder, Electrophysiology Department, Moorfields Eye Hospital, London EC1V 2PD, UK

https://doi.org/10.1136/bjo.85.9.1139c

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    Editor,—Vitravene (ISIS 2922, formerly known as fomivirsen sodium) is a phosphorothioate oligonucleotide with potent and specific anticytomegalovirus (CMV) activity.12Vitravene binds to human CMV mRNA and inhibits the synthesis of proteins responsible for regulating virus gene expression. It is given intravitreally and its site of action differs from currently available therapies therefore reducing viral cross resistance. Minimal adverse effects have been reported3 including peripheral visual field loss and retinal pigment changes at high doses but the mechanism of this is not known.4

    We report two patients in whom negative electroretinograms (ERGs) were observed following prolonged intravitreal vitravene.

    CASE REPORTS

    Patient 1

    A 51 year old man with AIDS developed CMV retinitis (CMVR) in the left eye in zones 2–3. The right eye was normal and visual acuity was 6/5 right, 6/6 left. The …

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