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Br J Ophthalmol 2002;86:108-113 doi:10.1136/bjo.86.1.108
  • Perspective

Evaluation of corneal graft rejection in a mouse model

  1. J Plšková,
  2. L Kuffová,
  3. V Holáň,
  4. M Filipec,
  5. J V Forrester
  1. Department of Ophthalmology, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK
  1. Correspondence to: Professor J V Forrester, Department of Ophthalmology, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK; jforrester{at}abdn.ac.uk
  • Accepted 20 April 2001

Abstract

Corneal graft rejection presents clinically and in experimental models as opacification and is considered to be the result of endothelial cell dysfunction or loss. However, recovery from opacification can occur suggesting either (a) that new endothelial cells can regenerate if the original cells were lost, or (b) that sufficient numbers of original cells can regain function if the opacification was due to temporary dysfunction. In this perspective, previous experimental studies of allograft rejection plus some new data are reviewed to support the latter mechanism.

Footnotes

    Responses to this article

    • Corneal opacification following keratoplasty in the rat model
      • Ilse Claerhout
      Br J Ophthalmol published online September 13, 2009

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