rss
Br J Ophthalmol 2002;86:80-83 doi:10.1136/bjo.86.1.80
  • Original Article

Retinoblastoma treated with primary chemotherapy alone: the significance of tumour size, location, and age

  1. Dan S Gombos1,2,
  2. Alison Kelly1,
  3. Pietro G Coen4,
  4. Judith E Kingston3,
  5. John L Hungerford1,2
  1. 1Ocular Oncology Service, St Bartholomew's Hospital, London, UK
  2. 2Ocular Oncology Service, Moorfields Eye Hospital, London, UK
  3. 3Paediatric Oncology Service, St Bartholomew's and the London NHS Trust, London, UK
  4. 4Department of Child Health, Royal London Hospital, London, UK
  1. Correspondence to: Mr J L Hungerford, Department of Ophthalmology, Ocular Oncology Service, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK
  • Accepted 20 April 2001

Abstract

Aims: To evaluate how tumour size, retinal location, and patient age affect the outcome of retinoblastoma foci treated with chemotherapy.

Methods: Retrospective review of retinoblastoma foci treated with primary chemotherapy alone. Individual tumours were coded with regard to their largest basal diameter, location within the eye (macula, macula to equator, equator to ora serrata), and patient's age at diagnosis. Successfully treated tumours required no further intervention while those requiring additional treatment were coded as failures.

Results: 56 (72%) tumours responded successfully to chemotherapy alone while 22 (28%) required additional therapy. 26 of 31 macular tumours (84%) and 30 of 47 extramacular tumours (64%) responded to chemotherapy (p <0.060). Relative to size, 46 of 60 tumours (77%) greater than 2 mm in basal diameter were successfully treated with chemotherapy, while only 10 of 18 tumours (56%) less than or equal to 2 mm responded (p <0.088). Among the eight tumour foci diagnosed in children less than 2 months of age, five (63%) failed to respond to chemotherapy alone (p <0.032).

Conclusion: Retinoblastoma is more likely to respond to primary chemotherapy if it is located in the macula and if the patient is older than 2 months of age. Tumours measuring less than 2 mm in diameter may be less responsive to this treatment.

Footnotes

    This Article

    1. Abstract
    2. Full text
    3. PDF

    Responses

    1. Submit a response
    2. No responses published

    Register for free content

    The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

    Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.