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Br J Ophthalmol 86:1114-1117 doi:10.1136/bjo.86.10.1114
  • Scientific correspondence

Lyophilisates for drug delivery in ophthalmology: pharmacokinetics of fluorescein in the human anterior segment

Table 1

Mean fluorescein concentrations (ng/ml) of cornea (C), anterior chamber (AC), and integral from corneal endothelium to anterior lens surface (AUC) over time after drop and lyophilisate application (n=12)

Cornea (C) Anterior chamber (AC) Area cornea-lens (AUC)
Time (minutes) Drop Lyophilisate Drop Lyophilisate Drop Lyophilisate
*Significant difference, p≤0.05.
0 8.25 7.45 3.58 2.60 1223.76 1168.97
15 23,23 772.88* 7.65 26.27* 1405.93 7161.68*
30 14.89 78.80 4.40 6.11* 1310.47 1749.74
45 12.50 23.22* 4.40 6.64* 1338.95 1469.35
60 10.41 20.88* 5.18 7.98* 1285.89 1426.35
120 12.94 15.81* 5.53 11.52* 1394.21 1537.00
180 10.23 20.91* 5.24 13.12* 1340.62 1686.18*

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