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In the recent literature there is controversy regarding the histopathological origin of retinoblastoma (RB) and retinal astrocytoma (RA). The common origin of both tumours from a multipotential stem cell has been studied in RB cell lines Y-79 and fresh RB materials with immunohistological techniques using GFAP (glial fibrillary acid protein), NSE (neuron specific enolase), photoreceptor cell markers (S-100, myelin basic protein), and synaptophysin.1–8 In immunohistopathological studies indications have been found for differentiation of RB into a neuronal and a partial glial pathway.1–8
To our knowledge no reports have been published on the simultaneous occurrence of both an RB and an RA in one eye. We present a case that demonstrates one eye of a 5 year old girl containing those two immunohistologically different tumours.
Case Report
In a 5 year old white girl a divergent strabismus of the right eye was discovered. No family history of RB or phacomatosis was present. Funduscopic examination under anaesthesia showed a central white mass. Nasally inferior in the peripheral retina a second large whitish mass with vitreous seeding on the …