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Br J Ophthalmol 86:156-158 doi:10.1136/bjo.86.2.156
  • Scientific correspondence

Sildenafil induces retinal vasodilatation in healthy subjects

Table 2

Systolic BP, diastolic BP, and pulse rate at baseline and at 30, 60, 90, and 120 minutes after sildenafil administration. Data are presented as mean (SD) (n=10)

Time after sildenafil administration (minutes) Systolic blood pressure (mm Hg) p Value Diastolic blood pressure (mm Hg) p Value Pulse rate (beats/min) p Value
One way ANOVA for systolic BP: F(4.36) = 4.7, p<0.004; for diastolic BP: F(4.36) = 1.51, p<0.22; for pulse rate: F(4.36) = 6.6, p<0.0004. p Values indicate significance of difference between values at baseline and sildenafil administration (*p<0.005).
Baseline 115.8 (7.7) 72.8 (4.3) 67 (9)
30 109.4 (6.0) <0.001 67.2 (3.9) 0.027 75 (8) <0.001
60 112.1 (9.5) 0.039 70.7 (9.3) 0.393 68 (9) 0.562
90 109.8 (8.0) 0.001 69.9 (5.6) 0.241 69 (7) 0.400
120 110.2 (10.6) 0.003 71.6 (6.3) 0.625 66 (5) 0.400

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