Br J Ophthalmol 86:521-523 doi:10.1136/bjo.86.5.521
  • Scientific correspondence

High dose intravenous steroid therapy for severe posterior segment uveitis in Behçet's disease

  1. N Acar
  1. Marmara University Medical School, Department of Ophthalmology
  1. Correspondence to: Ebru Toker, İnönü cad, Yildiz sok, STFA Bloklari, B-6, Daire 13, Kozyatağý, 81090, İstanbul, Turkey; aetoker{at}
  • Accepted 8 November 2001


Aim: To evaluate the safety and effectiveness of high dose intravenous steroid therapy (HDIST) in Behçet's disease patients with severe posterior segment uveitis attacks.

Methods: Five patients with ocular Behçet's disease were treated with HDIST for severe posterior segment attacks. Two patients had vasculitis, one patient had papillitis, and the other two had retinitis; four patients also had accompanying severe vitritis. The visual acuities and improvement in ocular signs after HDIST were evaluated.

Results: During HDIST, patients had no systemic complications caused by treatment. All patients responded to HDIST with evidence of a decrease in intraocular inflammatory activity and improved visual acuities within a mean time of 7 (1–15) days of commencing treatment. During follow up three out of five patients had new posterior segment attacks.

Conclusion: HDIST is effective in controlling severe, vision threatening acute posterior segment Behçet's uveitis attacks and in improving visual function in a short period of time