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Br J Ophthalmol 2002;86:706 doi:10.1136/bjo.86.6.706
  • Letter

Bilateral uveitis after intravesical BCG immunotherapy for bladder carcinoma

  1. M Wertheim,
  2. N Astbury
  1. Eye Department, Norfolk and Norwich University Hospital, Colney Lane, Norwich NR4 7UZ, UK Accepted for publication 13 February 2002
    • Accepted 13 February 2002

    Intravesical bacille Calmette-Guerin (BCG) is indicated for the treatment and prophylaxis of carcinoma in situ of the urinary bladder and prophylaxis of primary or recurrent papillary tumours.1 All previous reports of uveitis after intravesical BCG therapy have been associated with arthritis.1–4 HLA-B27 has been positive in all cases with uveitis.1–4 We describe a patient who is HLA-B27 negative with isolated bilateral uveitis after intravesical BCG therapy.

    Case report

    A 70 year old man presented to the eye casualty department with a 4 day history of bilateral red, painful, and photophobic eyes. He had no systemic complaints. He had no ophthalmic history of note. He had a medical history of hypertension, gout, and recurrent papillary transitional cell carcinoma of the bladder. Eight weeks previously he had been seen by a urologist for haematuria and increased frequency. …

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