Surgery for glaucoma in the 21st century
- Glaucoma and Wound Healing Research Units, MRC 5-FU Clinical Trial Team, Moorfields Eye Hospital and the Institute of Ophthalmology, University College London, UK
- Correspondence to: Professor P T Khaw, Wound Healing Research Unit, Glaucoma Unit and Divisions of Pathology and Cell Biology, Moorfields Eye Hospital and Institute of Ophthalmology, Bath Street London EC1V 9EL, UK;
How close are we to a utopian world?
Many of us who were brought up in the latter half of the 20th century will recall reading and watching science fiction programmes in the media predicting life in the 21st century. Apart from a life of leisure facilitated by intelligent computers and robots, we were meant to enjoy a prolonged life because of advances in science and technology. The few of us who did not have our genetic defects and predisposition to various diseases ironed out by the new “molecular surgery” would enjoy surgical correction with advanced technology including magic scalpels which left no scar. The surgery itself would be quick, have minimal complications, and require no postoperative care and manipulation, achieving the desired surgical “end point” in 95–100% of cases. Cataract surgery is nearly there, so how close are we to this utopian world with regard to glaucoma surgery?
In this issue of the BJO (p 748) O'Brart and colleagues report their randomised prospective study comparing viscocanalostomy with antimetabolite assisted trabeculectomy. In theory, the operation of viscocanalostomy is claimed to bring us one step closer to the restoration of normal drainage by dilating (with viscoelastic) and facilitating flow round Schlemm's canal without macroscopically penetrating the eye.1 There is some evidence that the dilatation of Schlemm's canal can be achieved at least for a short period with a viscoelastic injection, although the value of this is uncertain.
However, deroofing of Schlemm's canal and creation of a scleral lake are also carried out at the same time and there is anecdotal evidence that viscocanalostomy does not work without this component of the surgery. This component on its own is the operation known as non-penetrating deep sclerectomy. In theory, these procedures drain aqueous into scleral veins within the scleral lake rather that subconjunctivally in conventional drainage surgery, and it has been postulated that this may reduce the need for antiscarring agents. Leaving a remnant of meshwork may allow resistance to outflow, therefore reducing hypotony, preserving the blood-aqueous barrier, and possibly reducing long term cataract. In theory, minimal postoperative follow up is required as scleral flap manipulations used in conventional surgery cannot be done apart from Nd-YAG lasering of the remaining meshwork. So is this the way glaucoma surgery should be going in the 21st century?
Certainly, viscocanalostomy seems to have advantages compared to trabeculectomy in the early postoperative period with fewer complications such as transient hyphaema, anterior chamber shallowing and bleb leak. However, these were all transient. What is more relevant is that there were five postoperative cataracts requiring surgery in the trabeculectomy group (60% of whom had shallow anterior chambers and lower intraocular pressures in the early postoperative period) although intraocular pressure control was maintained after cataract surgery.
We have yet to achieve ideal glaucoma surgery
However, there were disadvantages to viscocanalostomy, which means it does not achieve the desired criteria for 21st century surgery at present. At 12 months 26% of the viscocanalostomy eyes had intraocular pressures of <15 mm Hg versus 76% of the trabeculectomy group, although postoperative Nd-YAG goniotomy was not performed in the first year, which has improved the success rate in other series of non-penetrating surgeries. This level of intraocular pressure control is now known to be associated with minimal glaucoma progression over nearly a decade of follow up.2 This finding of a higher “failure” rate based on intraocular pressure after “non-penetrating” surgery compared with trabeculectomy has been a finding in the majority of randomised trials comparing the two procedures.3–5
Viscocanalostomy or other similar procedures are not at present the procedure to replace trabeculectomy. Yet comparative studies offer us insights as to how we can move closer to this ideal. The early hypotony seen after trabeculectomy appears to play a significant part in cataract formation. This hypotony leads to a breakdown of the blood-aqueous barrier (albeit for a short time) which leads to leakage of growth factors, of which transforming growth factor β (TGF-β) is known to be particularly cataractogenic.6 This growth factor is autoinductive so even a short exposure can set off a self amplifying and perpetuating chain of events leading to cataract. It may be possible to neutralise this and other cataractogenic molecules with antibodies.7
Using relatively simple measures, it is now possible to prevent early postoperative hypotony after trabeculectomy in the perioperative and early postoperative period using a simple intraoperative anterior chamber infusion and releasable/adjustable sutures. The advantage of adjustable sutures is the pressure can be more easily adjusted down to the desired level postoperatively. It will be interesting to look at the incidence of cataract in patients in whom the early intraocular pressure has been very tightly controlled after trabeculectomy.
The presence of a bleb in patients undergoing viscocanalostomy strongly suggests that subconjunctival drainage is occurring, which is likely given that it is almost impossible to secure the outer scleral flap in non-penetrating surgery after a large inner scleral block has been removed. Therefore, accidental macroperforation (as opposed to microperforation which occurs during the deroofing procedure) of the meshwork leads to a high incidence of early hypotony. The more desirable diffuse blebs seen with viscocanalostomy can now be achieved with trabeculectomy, even with adjunctive mitomycin C, by using a larger scleral flap and a larger area of mitomycin C treatment, which considerably reduces bleb related complications.8 This also suggests that scarring processes may be important in non-penetrating techniques, and that the use of antiscarring techniques may increase the success rate of this surgery. Great care has to be taken if antimetabolites are used in non-penetrating surgery because of the danger of intraoperative intraocular penetration given the very deep dissections. Newer, less toxic antiscarring agents may improve this situation in the future.7
What is clear is that we are still some way from the perfection expected from surgery in the 21st century. However, simple methods are already available that could considerably improve the way we carry out trabeculectomy, which at presents appears much more likely to achieve the pressure reductions associated with arrest of glaucoma. We should, however, continue to strive to improve glaucoma surgery until we come close to the perfection we so desire. Current tube drainage devices do not meet this expectation9 and there are considerable technical obstacles to be overcome until we can ensure that they do.10
The keys to this ideal surgery lie in our ability to understand and control two processes—aqueous flow and the healing response of the eye. We must therefore be open to advances in all fields including less popular areas such as aqueous flow regulation, and newer areas including innovative surgical techniques, biological materials, nanotechnology, and molecular and cell biology. Only then will we be carrying out a 5 minute “procedure” with 95+% of patients achieving pressures in the 10–12 mm Hg range for several decades after surgery without complications (while the nerve is being regenerated). Impossible? Only if we think so.
The authors are supported by the Medical Research Council (UK) grant G9330070, Department of Health/Department of Trade and Industry link award, and the International Glaucoma Association.
Note in Proof
How close are we to a utopian world?