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Acquired ocular toxoplasmosis in pregnancy
  1. M Ramchandani1,
  2. J B Weaver2,
  3. D H M Joynson3,
  4. P I Murray4
  1. 1Birmingham and Midland Eye Centre, City Hospital NHS Trust, Dudley Road, Birmingham, UK
  2. 2Birmingham Women’s Hospital, Metchley Park Road, Birmingham, UK
  3. 3Toxoplasma Reference Unit, Public Health Laboratory, Singleton Hospital, Swansea, UK
  4. 4Birmingham and Midland Eye Centre, City Hospital NHS Trust, Dudley Road, Birmingham, UK
  1. Correspondence to: Professor P I Murray, Academic Unit of Ophthalmology, Birmingham and Midland Eye Centre, City Hospital NHS Trust, Dudley Road, Birmingham B18 7QU, UK; P.I.Murray{at}bham.ac.uk

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We describe the management of a case of acquired ocular toxoplasmosis that occurred in the first trimester of pregnancy.

Case report

A 27 year old apparently healthy Pakistani woman, at 9 weeks’ gestation, presented to the Birmingham and Midland Eye Centre with a 1 week history of blurred vision in the left eye. She had no past ocular problems. Her first uncomplicated pregnancy was 2 years previously. On examination, the best corrected visual acuities were 6/6 in each eye. The anterior segments were normal and the intraocular pressures were 16 mm Hg right eye, 14 mm Hg left eye. Funduscopy showed a diffuse, elevated white lesion in the left retina half a disc diameter in size located one disc diameter superior to the fovea (Fig 1). There was an area of associated perivascular sheathing and minimal vitreous activity. An active left retinochoroiditis with associated retinal vasculitis was diagnosed. The right fundus was normal.

Figure 1

Left fundus showing active retinochoroiditis with retinal vasculitis.

Serological testing revealed antibodies to Toxoplasma gondii at a titre of 1/4096 (2000 IU/ml) using the dye test and a toxoplasma IgM enzyme linked immunosorbent assay (ELISA) on the patient’s peripheral blood was positive. Subsequent serological tests at the PHLS Toxoplasma Reference Unit, Swansea, confirmed these results and IgG avidity testing demonstrated that the infection was acute (Table 1). The polymerase chain reaction (PCR) on peripheral blood for T gondii was negative.

Table 1

Serum dye test titres, IgM levels, and IgG avidity levels

At 3 weeks after presentation (12 weeks’ gestation), the patient’s visual acuities were unchanged. There was now occlusion of a small retinal arteriole crossing the lesion. After consultation with the obstetrician the patient decided to proceed with the pregnancy. She was commenced on oral spiramycin 1 g three times daily.

Eight weeks after presentation (17 weeks’ gestation) the vision remained the same and the focus of retinochoroiditis was beginning to scar. The patient underwent an amniocentesis for PCR against T gondii. This was negative suggesting the fetus was unaffected. Spiramycin was continued until the end of pregnancy. Sequential fetal ultrasounds were normal.

At term the patient gave birth to a healthy baby girl. Polymerase chain reaction (PCR) and culture for T gondii were negative on placental tissue. Nevertheless, the dye test on cord blood was positive at 500 IU/ml. As toxoplasma IgM ELISA, IgM, and IgA ISAGA on cord blood were negative, the positive dye test was probably detecting passively transferred maternal IgG. The mother’s vision remained normal, and only a small, pigmented scar was present (Fig 2).

Figure 2

Left fundus showing healed area of previous retinochoroiditis.

Comment

In the United Kingdom ocular toxoplasmosis is normally thought to occur through the congenital route, although recent evidence suggests that we may be underestimating the amount of acquired disease.1–6

Overall, about 40% of primary maternal infections lead to congenital infection of children,7 with a transplacental transmission rate of T gondii reported to be 3% in the first trimester, 22% in the second, and 63% in the third.8

In our case the features supporting an acquired aetiology included lack retinal scars from previous infection, and the positive IgM serology and IgG avidity results.9 Sera taken early in infection (<3 months) usually have avidity levels of less than 30%. Most sera taken later in infection (>6 months) have avidity levels of greater than 40%.

There are conflicting reports on the value of the PCR to detect toxoplasma DNA.10–12 This may represent the different target DNA strands used in the studies. The negative PCR result on the mother’s serum in our report is therefore not surprising. A negative PCR on amniotic fluid suggested that the fetus was not infected by toxoplasma, which was supported by the normal fetal ultrasounds.

Spiramycin is effective in reducing the risk of transmission to the fetus and therefore was given throughout pregnancy. This treatment may have contributed to the resultant good outcome for both mother and fetus.

Determining an aetiology of acquired T gondii infection was important in this patient as it allowed the most appropriate management plan to be initiated resulting in an excellent outcome. Acquired ocular toxoplasmosis occurring in pregnancy is rare and we hope this case report will raise the awareness of this unusual presentation.

References

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