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Letter
Tacrolimus
  1. D B Lake,
  2. T R G Poole
  1. Frimley Park Hospital, Portsmouth Road, Camberley, Surrey GU16 7UJ, UK

    https://doi.org/10.1136/bjo.87.1.121

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      Tacrolimus (FK506) is a highly immunosuppressive agent, in particular tacrolimus inhibits the formation of cytotoxic lymphocytes which are mainly responsible for graft rejection. We report only the second case of bilateral optic neuropathy associated with tacrolimus.

      Case report

      A 38 year old man with cystic fibrosis underwent pancreatic transplantation in 1999. He had been taking 4 mg of tacrolimus twice daily since his transplantation, and had never previously taken cyclosporin because of renal impairment.

      He had previously complained of gradual deterioration in vision of over 6 months duration, at which time he had been seen at another centre where visual acuity was noted to be 6/36 improving to 6/24 with pinhole bilaterally. Six months …

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