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Br J Ophthalmol 87:90-95 doi:10.1136/bjo.87.1.90
  • Original Article
    • Clinical science

Thermochemotherapy in hereditary retinoblastoma

Table 5

Differences between tumours with and without local recurrence after TCT. (Values are mean (SD))

Parameter No recurrence Recurrence p Value
Tested with Wilcoxon signed rank test. *Values for tumours >2 mm tumour height.
Number of treated tumours (n) 34 (62%) 21 (38%)
Number of tumours per eye before TCT (n) 4.0 (1.6) 3.8 (1.8) 0.63
Age at start of treatment (years) 0.78 (0.6) 0.69 (0.62) 0.8
Tumour diameter (mm) 5.4 (3.0) 7.9 (4.7) <0.0001
Tumour height (mm) 2.9 (1.8) 4.5 (2.5) <0.0001
Distance to optic disc (mm) 2.75 (2.73) 2.14 (2.27) 0.19
Number of TCT sessions (n) 4.2 (1.6) 4.4 (1.6) 0.76
Total duration of TCT (minutes) 54.1 (29.7) 63.8 (32.5) 0.07
Mean power during TCT session (mW) 493 (212) 613 (190) <0.0001
Mean total energy applied during TCT (J) 1677 (1086) 2340 (1250) (2601 ± 1207)* 0.001 (0.02)*
Mean energy/tumour volume applied during TCT (J/mm3) 183 (220) 497 (1077) (48 ± 65)* <0.0001 (<0.0001)*

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