Corneal fibrotic wound repair
- University of Florida Health Science Center, 1600 SW Archer Road, Gainsville, FL 32610–0294, USA; schultzg@obgyn.ufl.edu
It may be possible to regulate corneal scarring by controlling the activity of key genes
Corneal scarring following trauma, infections, or refractive surgery can produce blinding complications, but current treatment options are limited and outcomes are typically poor. Thus, there is a need for new treatments that will prevent or reduce corneal scarring with minimal side effects. To accomplish this, however, the basic processes that regulate corneal scarring need to be understood more thoroughly. Corneal wound healing is an exceedingly complex process that is coordinated and regulated in large part by autocrine and paracrine interactions of growth factors, cytokines, and …
