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Br J Ophthalmol 87:1312-1316 doi:10.1136/bjo.87.11.1312
  • Clinical science
    • Scientific reports

Evaluation of umbilical cord serum therapy for persistent corneal epithelial defects

Table 4

Rate of healing in the two groups using different parameters

Outcome variables Percentage decrease Statistical significance (Wilcoxon rank sum test)
Autologous serum group (n = 29) Umbilical cord serum group (n = 31) Z value p Value
Median (range) Median (range)
Horizontal diameter
Day 3 8.3 (−133.3–56.5) 3.0 (−220.0–57.1) 0.50 0.614
Day 7 10.0 (−100.0–100.0) 24.1 (−14.3–100.0) 1.16 0.244
Day 14 11.7 (–60.0–37.5) 30.4 (–6.1–100.0) 1.81 0.068
Day 21 13.1 (–55.0–50.0) 33.9 (–7.9–100.0) 1.37 0.184
Vertical diameter
Day 3 9.5 (–210.0–86.8) 3.2 (–960.0–33.33) 0.49 0.618
Day 7 9.8 (–77.1–100.0) 22.5 (–100.0–100.0) 0.90 0.364
Day 14 9.3 (–82.7–53.3) 23.5 (–100.0–100.0) 0.96 0.333
Day 21 11.9(–85.7–53.3) 20.0 (–100.0–100.0) 0.35 0.724
Area
Day 3 0.7 (–657.6–82.3) 11.5 (–1351.6–65.1) 0.49 0.619
Day 7 2.9 (–66.5–14.9 ) 53.0 (–48.0–100.0) 2.36 0.018
Day 14 13.8(–42.9–32.5) 63.0 (0.0–86.7) 2.72 0.013
Day 21 6.7 (–41.7–33.1) 62.7 (0.0–79.6) 2.57 0.009
Perimeter
Day 3 1.2 (–589.7–73.1) 13.2 (–366.85–66.34) 0.59 0.558
Day 7 3.1 (–38.2–14.3) 32.5 (–48.6–100.0) 2.69 0.007
Day 14 6.5 (–18.4–30.5) 48.5 (0.0–61.3) 2.30 0.021
Day 21 2.7 (–17.8–30.3) 48.9 (0.0–75.5) 2.24 0.024
Major axis (automated)
Day 3 3.3 (–121.5–44.6) 11.3 (–209.5–55.1) 0.00 1.000
Day 7 4.8 (–93.8–16.4) 65.0 (–17.4–100.0) 2.86 0.004
Day 14 9.5 (–48.3–26.6) 62.7 ( 0.0–85.2) 2.32 0.020
Day 21 5.6 (–47.9–25.5) 67.1 (0.0–75.1) 2.41 0.015
Minor axis (automated)
Day 3 2.9 (–214.4–74.2) 17.2 (–642.8–41.7) 0.29 0.770
Day 7 2.6 (–10.9–23.7) 54.2 (–75.2–100.0) 2.64 0.008
Day 14 4.9 (–4.9–35.8) 51.0 (–89.4–70.7) 1.51 0.129
Day 21 6.2 (–4.9–28.4) 41.7 (–75.2–64.8) 1.34 0.180

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