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Laboratory science - Extended reports
In vitro and in vivo study of lens refilling with poloxamer hydrogel
  1. Y K Han1,
  2. J W Kwon2,
  3. J S Kim2,
  4. C-S Cho3,
  5. W R Wee2,
  6. J H Lee2
  1. 1Department of Ophthalmology, Seoul Municipal Boramae Hospital, Korea
  2. 2Department of Ophthalmology, Seoul National University College of Medicine, Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Korea
  3. 3School of Agricultural Biotechnology, Seoul National University, Korea
  1. Correspondence to: Jin Hak Lee Department of Ophthalmology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea; jjhleeplaza.snu.ac.kr

Abstract

Aim: To evaluate the compatibility of poloxamer hydrogel as a material for an injectable intraocular lens, in vivo and in vitro.

Methods: The appropriate concentration of poloxamer hydrogel was determined for injection by examining the transparency and gelling temperature of this material, assessing the lens capsule refilling technique, and studying the postoperative findings in a rabbit model.

Results: Poloxamer hydrogel showed excellent transparency and 25% was identified as an appropriate concentration for the lens refilling material. The authors developed a technique for injecting the material in vivo and obtained excellent short term results.

Conclusions: Poloxamer hydrogel was identified as an appropriate material for direct lens refilling, and the developed injection technique produced excellent short term results.

  • injectable intraocular lens
  • lens refilling
  • poloxamer hydrogel
  • rabbit model

https://doi.org/10.1136/bjo.87.11.1399

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