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Br J Ophthalmol 2003;87:305-306 doi:10.1136/bjo.87.3.305
  • Original Article
    • Clinical science

Influence of factor V Leiden on the development of neovascularisation secondary to central retinal vein occlusion

  1. C Hvarfner1,
  2. A Hillarp2,
  3. J Larsson1
  1. 1Department of Ophthalmology, Lund University Hospital, Sweden
  2. 2Department of Clinical Chemistry, Malmö University Hospital, 211 85 Malmö, Sweden
  1. Correspondence to: Charlotte Hvarfner, Department of Ophthalmology, Lund University Hospital, 211 85 Lund, Sweden; charlotte.hvarfner{at}oft.lu.se
  • Accepted 4 September 2002

Abstract

Aims: To investigate if the presence of factor V Leiden has an influence on the prognosis in central retinal vein occlusion (CRVO).

Methods: 166 patients with CRVO were studied retrospectively. They were tested for factor V Leiden using DNA analysis. The presence of the mutation was studied in correlation with the development of neovascular complications 1 year after the thrombotic event.

Results: 56 of 166 patients (34%) developed neovascular complications after 1 year. In the patients who had the studied mutation 11 of 20 (55%) had developed neovascular complications after 1 year, compared to 45 of 146 patients (31%) in the group without factor V Leiden (p=0.04).

Conclusion: The presence of factor V Leiden seems to enhance the risk of developing neovascular complications in CRVO.

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