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Br J Ophthalmol 2003;87:362-363 doi:10.1136/bjo.87.3.362
  • Letter

Treatment of atopic blepharitis by controlling eyelid skin water retention ability with ceramide gel application

  1. N Asano-Kato1,
  2. K Fukagawa1,
  3. Y Takano1,
  4. T Kawakita1,
  5. K Tsubota1,
  6. H Fujishima1,
  7. S Takahashi2
  1. 1Department of Ophthalmology, Tokyo Dental College, Japan
  2. 2Department of Dermatology
  1. Correspondence to: Naoko Asano-Kato, MD, Department of Ophthalmology, Tokyo Dental College, Chiba, Japan, 5-11-13 Sugano, Ichikawa-shi, Chiba 272-8513, Japan; naokato{at}bc.iij4u.or.jp
  • Accepted 15 July 2002

Atopic blepharitis is one of the major ocular complications of atopic dermatitis (AD).1,2 It has been pointed out that atopic patients have dry skin accompanied by barrier disruption and water deficiency. Previously, we assessed the water retention ability of eyelid skin by measuring the water content and water evaporation rate from the eyelid in patients with atopic blepharitis.3 The water content positively correlated and water evaporation from the eyelid negatively correlated with the severity of blepharitis.3

Ceramide comprises about 30% of stratum corneum lipids, which have an important role in both the water retention and barrier function of the skin.4 Ceramide abnormalities in several skin disorders, such as AD, have been reported.5,6 Decreased levels of ceramides may be attributable …

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