rss
Br J Ophthalmol 2003;87:396-398 doi:10.1136/bjo.87.4.396
  • Singapore SERI-ARVO Meeting

Risk factors for conjunctival squamous cell neoplasia: a matched case-control study

  1. W Tulvatana1,
  2. P Bhattarakosol2,
  3. L Sansopha3,
  4. W Sipiyarak1,
  5. E Kowitdamrong2,
  6. T Paisuntornsug3,
  7. S Karnsawai3
  1. 1Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
  2. 2Department of Microbiology
  3. 3Department of Pathology
  1. Correspondence to: Wasee Tulvatana, MD, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Road, Bangkok 10330, Thailand; wasee{at}softhome.net
  • Accepted 6 January 2003

Abstract

Aims: To identify roles of human papillomavirus (HPV) infection and solar elastosis as the risk factors for conjunctival squamous cell neoplasia (CSCN).

Methods: 30 consecutive pathological specimens, ranging from conjunctival intraepithelial neoplasia, carcinoma in situ, to invasive squamous cell carcinoma were retrieved from tissue archives. 30 controls were disease free conjunctiva from age and sex matched patients undergoing extracapsular cataract extraction. Two masked pathologists studied haematoxylin and eosin stains on paraffin embedded conjunctival tissues. Elastic stain for solar elastosis was blindly interpreted in comparison with negative and positive controls. HPV infection was studied by polymerase chain reaction and dot hybridisation.

Results: The mean age of CSCN patients was 54.9 years. The male to female ratio was 1:1. Solar elastosis was seen in 53.3% of CSCN and in 3.3% of controls with an odds ratio of 16.0 (95% CI, 2.49 to 670.96; p value = 0.0003). HPV DNA were not detected in any of the specimens.

Conclusion: Solar elastosis is much more frequently found in CSCN cases than in their matched controls and is a risk factor for CSCN. These data are insufficient to conclude that HPV infection is a risk factor for CSCN.

Footnotes

    This Article

    1. Abstract
    2. Full text
    3. PDF

    Responses

    1. Submit a response
    2. No responses published

    Register for free content

    The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

    Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.