Article Text
Statistics from Altmetric.com
Phenylephrine 10% leads to a faster and more pronounced mydriasis but cardiovascular effects like hypertension and arrhythmias have been reported. In a young healthy adult the upper limit of safety for intravenous administration of phenylephrine is 1.5 mg1 and Kumar et al2 had found phenylephrine plasma levels after administration of topical 10% viscous solution to their patients to be 1.842–11.526 ng/ml after 20 minutes while topical 2.5% aqueous solution produced plasma levels of 0–1.720 ng/ml after 20 minutes. They concluded that the mean pressure tended to be higher with the 10% viscous solution.
Chin et al,3 in their study on 89 patients, concluded that significant hypertensive effects can arise after topical phenylephrine; however, no significant difference between the two groups (2.5% v 10%) was shown. Symons et al4 reported no significant change in the mean systolic and diastolic blood pressure in …