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Corneal deposits after the topical use of ofloxacin in two children with vernal keratoconjunctivitis
  1. I Claerhout1,
  2. Ph Kestelyn1,
  3. F Meire1,
  4. J-P Remon2,
  5. T Decaestecker3,
  6. J Van Bocxlaer3
  1. 1Department of Ophthalmology, Ghent University Hospital, Belgium
  2. 2Laboratory of Pharmaceutical Technology
  3. 3Laboratory of Medical Biochemistry and Clinical Analysis, Ghent University, Belgium
  1. Correspondence to: Françoise Meire, Department of Ophthalmology, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium; fran\|[ccedil]\|oise.meire{at}rug.ac.be

https://doi.org/10.1136/bjo.87.5.646

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    Topical fluoroquinolones are broad spectrum, bactericidal agents with activity against both Gram positive and Gram negative corneal pathogens. Single drug administration with topical fluoroquinolones has been effectively used in treatment of bacterial ulcerative keratitis. The drugs are safe, but a white crystalline deposit, that in most cases spontaneously dissolved, has been reported1–4 with ciprofloxacin 0.3% and norfloxacin 0.3%. Up to now this side effect has not been described with ofloxacin 0.3%. We present two children with severe vernal conjunctivitis who developed corneal deposits after use of ofloxacin 0.3% eye drops.

    Material and methods

    Patient 1

    A 6 year old boy with vernal keratoconjunctivitis (VKC) developed a painful right eye while on holiday. His ophthalmologist diagnosed a corneal ulcer and prescribed ofloxacin eye drops followed by ofloxacin ointment four times a day for 3 weeks, associated with prednisolone drops. As the inflammation in the right eye persisted, the child was referred to our department. Slit lamp examination revealed mild VKC and a corneal ulcer with a …

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