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Br J Ophthalmol 2003;87:833 doi:10.1136/bjo.87.7.833
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High and low chromosome instability separates retinoblastomas

Evidence from a cytogenetic study supports the idea that retinoblastoma may exist in two distinct forms which differ clinically. Eleven of 13 children in the study had chromosome abnormalities in their tumour—an array of gains /losses in various chromosomes—including those other than in chromosome 13q where the …

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