Mooren’s ulcer resolved with campath-1H
- Department of Ophthalmology, Aberdeen Royal Infirmary, Aberdeen, UK
- Correspondence to: Augusto Azuara Blanco, MD PhD, Ophthalmology Department, Aberdeen Royal Infirmary, The Eye Clinic, Foresterhill, Aberdeen AB25 2ZN, UK; aazblanco{at}aol.com
- Accepted 13 December 2002
Mooren’s ulcer is a rare idiopathic peripheral ulcerative keratitis. The diagnosis is usually based on characteristic clinical features and absence of other causes of peripheral keratitis. The clinical course can be unremitting, particularly in bilateral disease, occasionally leading to total loss of stroma.1,2
An autoimmune process is recognised as being central to the pathogenesis.
Calgranulin-C (CaGC), produced by granulocytes and also expressed by keratocytes, appears to be the target protein for the autoimmune response that leads to Mooren’s ulcer. Previous corneal trauma2 and a higher prevalence of HLA class II subtypes have been associated with Mooren’s ulcer.
The disease responds to immunosuppression with variable success. Surgical treatments such as conjunctival …
