Table 2
p Values* for comparison of GFAP immunoreactivity† between different histopathological groups for the three regions analysed
| Comparison groups§ | Region¥ | Immunolabelling intensity | Immunolabelling area |
|---|---|---|---|
| *p Values obtained using the Student’s t test. NS = not significant (p>0.05) by both Student’s t test and ANOVA with Student-Newmann-Keuls post hoc test. | |||
| ¶ = significant (p<0.05) by ANOVA with Student-Newmann-Keuls post hoc test. | |||
| †GFAP immunoreactivity assessed for two parameters: Immunolabelling intensity (total fluorescence intensity and area (sum of particle analyses of fields labelled). | |||
| §Comparisons made between AMD (drusen and GA, geographic atrophy) and controls (AN, aged normal and YN, young normal); also between AN and YN. | |||
| ¥Three regions of GFAP expression: inner retina (within NFL/GCL); outer retina (OLM to IPL/INL); total = inner retina + outer retina. | |||
| Drusen v YN | Inner retina | 0.0036 | 0.002 |
| Outer retina | NS | NS | |
| Total | 0.0022 | 0.0018 | |
| Drusen v AN | Inner retina | 0.0298 | 0.0139 |
| Outer retina | NS | NS | |
| Total | 0.0179 | 0.0104 | |
| GA v YN | Inner retina | NS | 0.0397 |
| Outer retina | 0.0573¶ | 0.0341 | |
| Total | 0.0397 | 0.0207 | |
| GA v AN | Inner retina | NS | NS |
| Outer retina | 0.0619¶ | 0.0368 | |
| Total | 0.0692¶ | 0.0449 | |
| GA v Drusen | Inner retina | NS | NS |
| Outer retina | 0.0359 | 0.0267 | |
| Total | NS | NS | |
| AN v YN | Inner retina | NS | NS |
| Outer retina | NS | NS | |
| Total | NS | 0.0383 | |
