Behçet’s disease: from Hippocrates to the third millennium
- 1St Thomas’s Hospital, London, UK
- 2Birmingham and Midland Eye Centre, Birmingham, UK
- 3Clinical Transplantation Laboratory, Guy’s, King’s and St Thomas’ Hospital Medical Schools, London, UK
- Correspondence to: D H Verity and M R Stanford, Medical Eye Unit, Thomas’s Hospital, London, UK; veritydh{at}hotmail.com
- Accepted 29 April 2003
Abstract
Behçet’s disease (BD) is characterised by recurrent episodes of orogenital aphthae, systemic vasculitis, and systemic and retinal venous thrombosis. An association between HLA-B51 and BD was first identified over 20 years ago, but recently identified gene associations implicate regions both within and without the MHC in the immunological events underlying the lesions in BD. These include allelic variants within the tumour necrosis factor gene region and within the MHC class I chain related gene region, the factor V Leiden mutation, which is associated with retinal vascular occlusion, and alleles of the intercellular adhesion molecule gene. No single causative gene for BD has emerged; the evidence indicates that the underlying immune events in BD are triggered by a microbial antigen and subsequently driven by genetic influences which control leucocyte behaviour and the coagulation pathways. Knowledge of these risk factors may permit a more accurate prognosis for a given patient, and identify new pathways for more targeted intervention than is currently available.
