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Br J Ophthalmol 2004;88:17-18 doi:10.1136/bjo.88.1.17
  • Clinical science
    • Scientific reports

Mitomycin C as an adjunct in the treatment of localised ocular surface squamous neoplasia

  1. C Chen1,
  2. D Louis1,
  3. T Dodd2,
  4. J Muecke1
  1. 1Ophthalmic Oncology Unit, Department of Ophthalmology, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia
  2. 2Institute of Medicine and Veterinary Science, Frome Road, Adelaide, SA 5000, Australia
  1. Correspondence to: Dr James Muecke Department of Ophthalmology, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia; raheyesmail.rah.sa.gov.au
  • Accepted 5 April 2003

Abstract

Aim: To report the outcome of topical mitomycin C (MMC) used as adjunctive treatment following primary excision of ocular surface squamous neoplasia (OSSN).

Method: Prospective, non-comparative interventional case series of 27 primary OSSN lesions from 26 patients treated in a single ocular oncology centre over a 4 year period.

Result: 27 cases of OSSN received a treatment regimen of surgical excision, followed by topical MMC. Mean follow up of 27 (SD 12) months (range 12–50, median 25 months) revealed zero recurrences.

Conclusion: MMC treatment following surgical excision decreases the recurrence rate of primary ocular surface neoplasia and should be considered as adjunctive therapy in primary treatment.

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