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Br J Ophthalmol 2004;88:1353 doi:10.1136/bjo.2004.042861/045120
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Blue light and the circadian clock

  1. R N Van Gelder1
  1. 1Washington University Medical School, Campus Box 8096, 660 S Euclid Avenue, St Louis, MO 63110, USA; vangelder@vision.wustl.edu
    • Accepted 22 January 2004

    Drs Mainster and Sparrow have provided an excellent perspective on the relative merits and difficulties of extending intraocular lens (IOL) absorption into the blue portion of the spectrum.1

    However, they have not considered an unintentional consequence of blockage of the blue portion of the spectrum—reducing the activity of intrinsically photosensitive retinal ganglion cells.2,3 These cells subserve several non-visual ocular photoreceptive tasks, most prominently the entrainment of the circadian clock to external light-dark cycles.4 Pupillary light responses in mice are also …

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