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Br J Ophthalmol 88:236-238 doi:10.1136/bjo.2003.025056
  • Clinical science
    • Scientific reports

Surgery for primary basal cell carcinoma including the eyelid margins with intraoperative frozen section control: comparative interventional study with a minimum clinical follow up of 5 years

Table 1

Clinicopathological characteristics of the study groups

Characteristic Group I (n = 114) Group II (n = 31) p Value
*Defined as involvement of the medial quarter of the upper or lower lid and/or the angle.
†Defined as involvement of the lateral quarter of the upper or lower lid and/or the angle.
‡Refers to maximal tumour diameter.
§Infiltrative growth component was defined as a portion or all of the tumour consisting of elongated strands of infiltrating BCC tumour cells.
¶Positive margins were defined as the presence of tumour cells at one or more cut surfaces of the surgical specimen.
N, number; N/A, not applicable; PPS, postoperative paraffin section.
Mean age (range) (years) 71.5 (44–94) 65.9 (45–91) N/A
Female:male ratio 1.0:0.9 1.0:1.3 N/A
Anatomical location, n (%)
    Medial canthal region* 55 (48.2) 11 (35.5) p<0.05
    Lower lid, central 33 (28.9) 10 (32.2) p>0.05
    Lateral canthal region† 20 (17.5) 7 (22.6) p>0.05
    Lower lid, entire lid 5 (4.5) 3 (9.7) p>0.05
    Upper lid, central 1 (0.9) 0 (0.0) p>0.05
Mean tumour size (range) (mm)‡ 13.3 (2–32) 12.9 (5–18) N/A
Histopathology§
    Infiltrative growth pattern, n (%) 24 (21.0) 7 (22.6) p>0.05
    Circumscribed growth pattern, n (%) 90 (79.0) 24 (77.4) p>0.05
Histopathological margins¶
    Positive margins on PPS, n (%) 0 (0.0) 3 (9.7) p = 0.002
Follow up and recurrence rate p = 0.002
    Mean follow up period (range) (years) 6.4 (5.0–11.1) 6.9 (5.0–14.1)
    Recurrences after resection, n (%) 0 (0.0) 3 (9.7)
    Mean time to recurrence (range) (years) N/A 5.1 (1.9–10.6)

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