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Br J Ophthalmol 88:303-305 doi:10.1136/bjo.2003.023945
  • Letter

HLA typing is not predictive of proliferative diabetic retinopathy in patients with younger onset type 2 diabetes mellitus

Table 3

HLA-DQ and -DR antigen frequencies (%) in each group

Control v non-DR Control v PDR Non-DR v PDR
Control group Non-DR group PDR group χ2 p Value Odds ratios χ2 p Value Odds ratios χ2 p Value Odds ratios
Numbers in parentheses are percentages. NS  =  not significant. All p values were not significant other than DR4 with p = 0.036 in the control v non DR test and 0.014 in the control v PDR test.
DR1 4 (8.0) 3 (6.7) 4 (9.1) 0.062 NS 0.821 0.036 NS 1.150 0.180 NS 1.400
DR2 16 (32.0) 11 (24.4) 13 (29.5) 0.665 NS 0.688 0.066 NS 0.891 0.294 NS 1.296
DR3 0 (0.0) 0 (0.0) 0 (0.0) – NS – – NS – – NS –
DR4 15 (30.0) 23 (51.1) 26 (59.1) 4.398 0.036 2.439 5.937 0.014 2.804 0.932 NS 1.510
DR6 14 (28.0) 8 (17.8) 6 (13.6) 1.391 NS 0.556 2.883 NS 0.406 0.288 NS 0.730
DR7 1 (2.0) 0 (0.0) 0 (0.0) 0.910 NS 0.000 0.889 NS 0.000 – NS –
DR8 11 (22.0) 7 (15.6) 7 (15.9) 0.640 NS 0.653 0.561 NS 0.671 0.002 NS 1.027
DR9 24 (48.0) 14 (31.1) 13 (29.5) 2.815 NS 0.489 3.340 NS 0.454 0.026 NS 0.928
DR10 1 (2.0) 0 (0.0) 0 (0.0) 0.910 NS 0.000 0.889 NS 0.000 – NS –
DR11 1 (2.0) 1 (2.2) 4 (9.1) 0.006 NS 1.114 2.337 NS 4.900 1.979 NS 4.400
DR12 2 (4.0) 1 (2.2) 0 0.0 0.245 NS 0.545 1.798 NS 0.000 0.989 NS 0.000
DR13 8 (16.0) 3 (6.7) 2 (4.5) 2.015 NS 0.375 3.230 NS 0.250 0.189 NS 0.667
DR14 6 (12.0) 4 (8.9) 3 (6.8) 0.243 NS 0.715 0.726 NS 0.537 0.132 NS 0.750
DRHR5 1 (2.0) 1 (2.2) 0 (0.0) 0.006 NS 1.114 0.889 NS 0.000 0.989 NS 0.000
DRHR6 3 (6.0) 2 (4.4) 1 (2.3) 0.115 NS 0.729 0.798 NS 0.364 0.322 NS 0.500
DR52 19 (38.0) 13 (28.9) 9 (20.5) 0.880 NS 0.663 3.445 NS 0.420 0.850 NS 0.633
DR53 33 (66.0) 29 (64.4) 31 (70.5) 0.025 NS 0.934 0.214 NS 1.228 0.366 NS 1.316
DQ1 32 (64.0) 28 (62.2) 20 (45.5) 0.032 NS 0.926 3.257 NS 0.469 2.518 NS 0.506
DQ2 1 (2.0) 0 (0.0) 0 (0.0) 0.910 NS 0.000 0.889 NS 0.000 – NS –
DQ3 28 (56.0) 23 (51.1) 15 (34.1) 0.228 NS 0.821 3.625 NS 0.449 1.965 NS 0.547
DQ4 17 (34.0) 12 (26.7) 20 (45.5) 0.601 NS 0.706 1.287 NS 1.618 3.410 NS 2.292
DQ6 (1) 6 (12.0) 8 (17.8) 13 (29.5) 0.629 NS 1.586 4.468 NS 3.075 1.709 NS 1.940
DQ7 6 (12.0) 1 (2.2) 4 (9.1) 3.317 NS 0.167 0.208 NS 0.733 1.979 NS 4.400

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