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Br J Ophthalmol 2004;88:321-324 doi:10.1136/bjo.2003.025924
  • World views

Visual outcomes in children in Malawi following retinopathy of severe malaria

  1. N A V Beare1,
  2. C Southern1,
  3. K Kayira2,
  4. T E Taylor2,3,
  5. S P Harding1
  1. 1St Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, UK
  2. 2Malaria Project and Wellcome Trust Laboratories, College of Medicine, Blantyre, Malawi
  3. 3College of Osteopathic Medicine, Michigan State University, East Lansing, USA
  1. Correspondence to: Nicholas Beare FRCOphth, St Paul’s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK; nbearebtinternet.com
  • Accepted 11 August 2003

Abstract

Aim: To investigate whether retinal changes in children with severe malaria affect visual acuity 1 month after systemic recovery.

Methods: All children with severe malaria admitted to a research ward in Malawi during one malaria season were examined by direct and indirect ophthalmoscopy. Visual acuity was tested in those attending follow up by Cardiff cards, Sheridan-Gardiner single letters, or Snellen chart.

Results: 96 (68%) children attended follow up, of whom 83 (86%) had visual acuity measured. Cardiff cards were used in 47 (57%) children, and Sheridan-Gardiner letters or Snellen chart in 29 (35%). There was no significant difference in the mean logMAR visual acuity between groups with or without macular whitening (0.14 versus 0.16, p = 0.55). There was no trend for worse visual acuity with increasing severity of macular whitening (p = 0.52) including patients in whom the fovea was involved (p = 0.32). Six (4.2%) children had cortical blindness after cerebral malaria, and all six had other neurological sequelae. Ophthalmoscopy during the acute illness revealed no abnormalities in four of these children.

Conclusion: Retinal changes in severe malaria, in particular macular whitening, do not appear to affect visual acuity at 1 month. This supports the hypothesis that retinal whitening is due to reversible intracellular oedema in response to relative hypoxia, caused by sequestered erythrocytes infected by Plasmodium falciparum. Impaired visual functioning after cerebral malaria is not attributable to retinal changes and appears to be a cortical phenomenon.

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