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Br J Ophthalmol 88:412-416 doi:10.1136/bjo.2003.028506
  • Clinical science
    • Extended reports

Systemic CD4+ T cell phenotype and activation status in intermediate uveitis

Table 1

Median (interquartile range) percentage expression of CD69, chemokine receptors, and intracellular cytokines by peripheral blood CD4+ T cells of patients with intermediate uveitis and normal controls (**p = 0.002, *p<0.05 v controls)

Idiopathic intermediate uveitis Presumed sarcoid intermediate uveitis Normal controls
CCR4 31.3 (26.0–37.1) 25.6 (20.8–27.8) 31.5 (27.2–33.0)
CCR5 5.5 (3.3–9.2) 6.0 (3.3–8.1) 6.0 (21.5–9.6)
CXCR3 21.0 (12.0–35.0) 13.7 (8.9–23.0) 21.1 (10.2–36.5)
CD69 52.5 (46.7–58.2)** 53.8 (52.2–56.9)* 38.4 (29.8–47.8)
IL-10 unstimulated 0.2 (0.2–0.6) 0.4 (0.3–0.5) 0.3 (1.2–0.7)
IL-10 activated 0.7 (0.3–2.9) 1.2 (1.0–1.6) 0.8 (0.6–1.6)
TNFα unstimulated 4.3 (2.9–6.1) 4.3 (4.1–6.8) 4.4 (1.2–9.1)
TNFα activated 70.7 (61.4–76.1)* 71.1 (68.9–74.3)* 56.5 (52.8–70.2)
IFNγ unstimulated 0.4 (0.2–0.6) 0.6 (0.5–0.6) 0.3 (0.2–0.4)
IFNγ activated 6.5 (4.9–10.4) 8.4 (8.3–14.5) 7.3 (5.5–12.1)

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