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Br J Ophthalmol 2004;88:703-707 doi:10.1136/bjo.2003.021113
  • Laboratory science - Extended reports

Deposition of silicone oil droplets in the residual anterior lens capsule after vitrectomy and lensectomy in rabbits

  1. T Miyamoto1,
  2. S Saika1,
  3. A Yamanaka2,
  4. Y Okada1,
  5. Y Ohnishi1
  1. 1Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
  2. 2Department of Ophthalmology and Kobe Kaisei Hospital, Kobe, Hyogo, Japan
  1. Correspondence to: T Miyamoto M.D., Department of Ophthalmology, Wakayama Medical University, 811-1, Kimiidera, Wakayama-city, Wakayama, 641-0012, Japan; tmiyamwakayama-med.ac.jp
  • Accepted 1 August 2003

Abstract

Aim: To examine the histology of preserved anterior lens capsule in vitrectomised and lensectomised rabbit eyes with and without silicone oil tamponade.

Methods: Forty adult Japanese albino rabbits received two port vitrectomy and lensectomy with or without silicone oil tamponade in one eye under both general and topical anaesthesia. Anterior lens capsule was preserved during operation. After healing intervals residual anterior capsule was histologically observed under light or electron microscopy.

Results: Immediately after operation, cuboidal lens epithelial cells were observed on the posterior surface of the preserved anterior capsule. During healing intervals in eyes with or without silicone oil tamponade, regenerated lens structure of Sommerring’s ring and fibrous tissue formed in the peripheral and central areas of the residual capsule, respectively. Ultrastructural observation revealed the presence of many vacuoles amid matrix accumulation on the posterior capsular surface, suggesting the deposition of emulsified silicone oil droplets.

Conclusion: Lens epithelial cells produce regenerated lenticular structure and fibrous tissue on the residual capsule following vitrectomy and lensectomy in rabbits. Silicone oil droplets formed by its emulsification deposit in extracellular matrix accumulated on the posterior surface of the anterior capsule. Emulsified silicone may potentially enhance opacification of residual anterior capsule following pars plana vitrectomy by silicone oil deposition and subsequent activation of lens epithelial cells.

Footnotes

  • Commercial interest for all authors: none.

  • Presented by Dr Miyamoto in part at the annual meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, USA (May 1998, 1999, and 2001).

Responses to this article

  • Identification of silicone oil in ocular tissues
    • AKIHIRO OHIRA
    Br J Ophthalmol published online September 14, 2009

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