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Br J Ophthalmol 2004;88:718-719 doi:10.1136/bjo.2003.034215
  • Letter

Mitomycin C in sebaceous gland carcinoma with pagetoid spread

  1. K Tumuluri,
  2. G Kourt,
  3. P Martin
  1. Department of Oculoplastic and Orbital Surgery, Sydney Eye Hospital, Sydney, Australia
  1. Correspondence to: Dr Georgina Kourt Eye Associates, 149 Macquarie Street, Sydney 2000, Australia; ginaharrozemail.com.au
  • Accepted 26 September 2003

Sebaceous gland carcinoma is a rare eyelid tumour comprising less than 1% of all eyelid malignancies.1 It commonly arises from the meibomian glands of the tarsus, but may also arise from the glands of Zeis or from the sebaceous glands of caruncle.2 It can present in a nodular or diffuse infiltrative form. The latter form with intraepithelial (pagetoid) invasion has poor prognosis as a result of delay in diagnosis as well as more extensive involvement of ocular tissues. Topical application of mitomycin C, a non-cell cycle specific alkylating agent, has been advocated for pagetoid spread of sebaceous gland carcinoma.3 We report the use of mitomycin C as adjuvant therapy in a patient with completely excised sebaceous gland carcinoma and pagetoid …

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