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Br J Ophthalmol 88:803-808 doi:10.1136/bjo.2003.035915
  • Clinical science
    • Extended reports

Thyroid associated ophthalmopathy: evidence for CD4+ γδ T cells; de novo differentiation of RFD7+ macrophages, but not of RFD1+ dendritic cells; and loss of γδ and αβ T cell receptor expression

Table 2

Monoclonal antibodies and their characteristics

Antigen(s) Clone(s)* Isotype† Cellular reactivity
*Sources: DAKO, Hamburg, Germany (CR3/43); Serotec, Oxford, UK (all others).
†Mouse antihuman antibodies throughout.
‡Antibodies recognise the CD45 and CD45RB splicing variants.
§Antibody recognises a common αβ chain framework determinant.
¶Antibody recognises a monomorphic epitope present on all TCR Cγ domains.
CD4 1F6 IgG1 Mostly T helper cells
CD8 4B11 IgG2b Cytotoxic and T suppressor cells
CD14 UCHM1 IgG2a Monocytes; early tissue macrophage
CD20 7D1 IgG1 B lymphocytes
CD33 WM54 IgG1 Recently infiltrated blood monocytes
CD45 2B11+ PD7/26‡ IgG1 All leukocytes
T cell receptors αβ§ 8A3 IgG1 All T cells expressing αβ T cell receptors
T cell receptors γδ¶ γ 3.20 IgG1 All T cells expressing γδ T cell receptors
HLA-DR, DP, DQ, DX CR3/43 IgG1 MHC class II expressed by professional and facultative antigen presenting cells
RFD1 antigen RFD1 IgM Dendritic cells
RFD7 antigen RFD7 IgG1 Mature and inflammatory macrophages

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