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Retinal progenitor cells in the posterior pars plana of rhesus monkeys
  1. J B Jonas1,
  2. S Panda-Jonas1,
  3. S Singh Hayreh2
  1. 1Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany
  2. 2Departments of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa USA
  1. Correspondence to: Dr J Jonas Universitäts-Augenklinik, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; Jost.Jonasma.augen.uni-heidelberg.de

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    It has been generally assumed that the adult mammalian eye is devoid of retinal stem cells or progenitor cells as self renewing and multipotential cells. In a previous study, however, identification of retinal stem cells in the mouse eye has been reported, representing a possible substrate for retinal regeneration.1 It has been paralleled by other studies on multipotent precursor cells in the ciliary margin of the frog retina,2 the role of Muller glia for neural regeneration in the postnatal chicken retina,3 progenitor cell proliferation and horizontal cell genesis in the mammalian retina,4 and differentiation of human neural stem cells into retinal cells.5 The retinal progenitor or stem cells were thought to be located in the region of the ciliary body.1 Examining rhesus monkey eyes, it was the purpose of the present histological study to look for a region in the monkey pars plana area which could serve as nidus of retinal stem cells.

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    The study included 11 normal eyes of rhesus monkeys with a mean age of 18.2 (SD 2.8) years. The eyes had been enucleated, fixed in formaline, and prepared for light microscopy. An anterior-posterior segment going through the pupil and the optic nerve was cut …

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