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Br J Ophthalmol 2004;88:839-840 doi:10.1136/bjo.2003.034140
  • Letter

Morphallaxia-like ocular histology after intravitreal triamcinolone acetonide

  1. J B Jonas1,
  2. U Bleyl2
  1. 1Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, Ruperto-Carola-University Heidelberg, Germany
  2. 2Department of Pathology, Faculty of Clinical Medicine Mannheim, Ruperto-Carola-University Heidelberg, Germany
  1. Correspondence to: Dr J Jonas Universitäts-Augenklinik, Theodor-Kutzer-Ufer 1–3, 68167 Mannheim, Germany; Jost.Jonasaugen.ma.uni-heidelberg.de
  • Accepted 24 September 2003

Subretinal or retinal neovascularisation, intravitreal proliferation of non-vascular cells, intraretinal or subretinal oedema, and chronic ocular hypotony have recently been treated by intravitreal injections of steroids such as triamcinolone acetonide.1–3 The diseases included long standing macular oedema due to central retinal vein occlusion, diffuse diabetic macular oedema, exudative age related macular degeneration, proliferative diabetic retinopathy, neovascular glaucoma, proliferative vitreoretinopathy, chronic pre-phthisical ocular hypotony, chronic uveitis, persistent pseudophakic cystoid macular oedema, and other clinical conditions.1–3 Systemic or local side effects reported so far include cataract, secondary ocular hypertension leading in some patients to secondary chronic open angle glaucoma, non-infectious endophthalmitis or “pseudo-endophthalmitis,” and post-injection infectious endophthalmitis.4–6 Safety and toxicity investigations have not revealed a negative effect of intravitreal corticosteroids on intraocular structures, yet. Besides a recent report, other histological examinations of globes after intravitreal injections of triamcinolone acetonide in …

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