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Br J Ophthalmol 88:934-937 doi:10.1136/bjo.2003.033175
  • Clinical science
    • Extended reports

Childhood myopia and parental smoking

Table 2

 Ocular biometry and refraction parameters for different parental smoking history

Refractive error (D) Axial length (mm) Corneal curvature (mm)
Mean (95% CI) Adjusted mean* (95% CI) Mean (95% CI) Adjusted mean* (95% CI) Mean (95% CI) Adjusted mean* (95% CI)
For mother’s smoking, mean adjusted for age, sex, school, mother’s education, and mother’s myopia.
For father’s smoking, mean adjusted for age, sex, school, father’s education, and father’s myopia.
Mother who ever smoked during child’s lifetime
    No 1301 −1.37 (−1.48 to −1.26) −1.38 (−1.49 to −1.27) 23.87 (23.81 to 23.93) 23.87 (23.82 to 23.92) 7.76 (7.75 to 7.77) 7.76 (7.75 to 7.77)
    Yes 23 −0.36 (−0.79 to 0.07) −0.28 (−1.12 to 0.57) 23.32 (22.97 to 23.68) 23.34 (22.92 to 23.75) 7.72 (7.64 to 7.81) 7.74 (7.62 to 7.84)
    p Value 0.03 0.012 0.01 0.013 0.51 0.67
Number of cigarettes per day mother smoked during child’s lifetime
    0 1301 −1.37 (−1.48 to −1.26) −1.38 (−1.49 to −1.27) 23.87 (23.81 to 23.93) 23.87 (23.82 to 23.92) 7.76 (7.75 to 7.77) 7.76 (7.75 to 7.77)
    6 or fewer 13 −0.62 (−1.31 to 0.08) −0.62 (−1.18 to −0.05) 23.28 (22.70 to 23.87) 23.55 (23.27 to 23.84) 7.66 (7.53 to 7.79) 7.76 (7.69 to 7.83)
    7 or more 10 −0.02 (−0.48 to 0.44) +0.15 (−0.99 to 1.28) 23.38 (22.97 to 23.80) 23.24 (22.67 to 23.81) 7.80 (7.69 to 7.91) 7.76 (7.63 to 7.90)
    p Value (trend) 0.07 0.009 0.046 0.031 0.23 0.95
Number of years mother smoked during child’s lifetime
    Regression coefficient 1324 0.14 (0.03 to 0.24) 0.15 (0.041 to 0.25) −0.07 (−0.13 to −0.02) −0.07 (−0.12 to −0.015) −0.002 (−0.015 to 0.011) 0.00013 (−0.013 to 0.013)
    p Value (regression) 0.011 0.006 0.012 0.012 0.78 0.98
Father who ever smoked during child’s lifetime
    No 871 −1.40 (−1.55 to −1.26) −1.37 (−1.51 to −1.23) 23.88 (23.81 to 23.95) 23.85 (23.79 to 23.92) 7.75 (7.74 to 7.77) 7.75 (7.73 to 7.77)
    Yes 434 −1.24 (−1.42 to −1.06) −1.31 (−1.50 to −1.11) 23.82 (23.72 to 23.92) 23.87 (23.77 to 23.96) 7.77 (7.75 to 7.79) 7.78 (7.75 to 7.80)
    p Value 0.31 0.60 0.47 0.84 0.30 0.077
Number of cigarettes per day father smoked during child’s lifetime
    0 871 −1.40 (−1.55 to −1.26) −1.37 (−1.51 to −1.24 23.88 (23.81 to 23.95) 23.85 (23.79 to 23.91) 7.75 (7.74 to 7.77) 7.75 (7.74 to 7.77)
    6 or fewer 152 −1.30 (−1.61 to −0.99) −1.34 (−1.46 to −1.22) 23.84 (23.66 to 24.01) 23.86 (23.80 to 23.92) 7.77 (7.73 to 7.82) 7.76 (7.75 to 7.78)
    7–12 142 −1.34 (−1.67, −1.00) −1.30 (−1.49, −1.12) 23.84 (23.66, 24.02) 23.87 (23.78, 23.96) 7.77 (7.73, 7.81) 7.77 (7.75, 7.80)
    13 or more 139 −1.09 (−1.40 to −0.78) −1.27 (−1.55 to −0.99) 23.78 (23.63 to 23.94) 23.89 (23.75 to 24.02) 7.76 (7.72 to 7.81) 7.79 (7.75 to 7.82)
    p Value (trend) 0.52 0.53 0.88 0.67 0.68 0.092
Number of years father smoked during child’s lifetime
    Regression coefficient 1297 0.014 (−0.013 to 0.04) 0.008 (−0.020 to 0.036) −0.003 (−0.017 to 0.011) 0.0003 (−0.014 to 0.014) 0.002 (−0.0009 to 0.006) 0.003 (−0.0004 to 0.006)
    p Value (regression) 0.32 0.57 0.67 0.96 0.15 0.089

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