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Br J Ophthalmol 2004;88:1074-1077 doi:10.1136/bjo.2003.035642
  • Clinical science
    • Extended reports

A multicentre report from the Mexican Retinoblastoma Group

  1. C Leal-Leal1,
  2. M Flores-Rojo1,
  3. A Medina-Sansón2,
  4. F Cerecedo-Díaz3,
  5. S Sánchez-Félix4,
  6. O González-Ramella5,
  7. F Pérez-Pérez6,
  8. R Gómez-Martínez7,
  9. A Quero-Hernández8,
  10. E Altamirano-Álvarez9,
  11. F Alejo-González10,
  12. J Figueroa-Carbajal11,
  13. A Ellis-Irigoyen12,
  14. I Tejocote-Romero13,
  15. R Cervantes-Paz13,
  16. F Pantoja-Guillén14,
  17. L Vega-Vega15,
  18. F Carrete-Ramírez16
  1. 1Instituto Nacional de Pediatría, DF, Mexico
  2. 2Hospital Infantil de México Federico Gómez, DF, Mexico
  3. 3Centro Médico Nacional SXXI, DF, Mexico
  4. 4Centro Médico La Raza, DF, Mexico
  5. 5Hospital Civil de Guadalajara, Jalisco, Mexico
  6. 6Hospital General de México, DF, Mexico
  7. 7Centro Médico de Occidente IMSS, Jalisco, Mexico
  8. 8Hospital del Niño Oaxaqueño, Oaxaca, Mexico
  9. 9Hospital Pediátrico de Sinaloa, Sinaloa, Mexico
  10. 10Hospital Central de San Luis Potosí, San Luis Potosí, Mexico
  11. 11Hospital del Niño Morelense, Morelos, Mexico
  12. 12Hospital del Niño de Villahermosa, Tabasco, Mexico
  13. 13Instituto Materno Infantil de Estado de México, Mexico
  14. 14Hospital O’Horan de Mérida, Yucatan, Mexico
  15. 15Centro Estatal de Cancerología de Jalapa, Veracruz, Mexico
  16. 16Hospital General de Durango, Durango, Mexico
  1. Correspondence to: Dr C Leal-Leal Insurgentes Sur 3700-c Mexico 04530 Mexico City, Mexico; drcarlosalealmsn.com
  • Accepted 7 January 2004

Abstract

Background: Retinoblastoma (RB) is a relatively uncommon tumour in childhood. The incidence of retinoblastoma in Mexico is probably higher than the incidence reported worldwide, however there is not enough information about the characteristics of this illness in Mexico. This report aims to present the results of a multicentre clinical survey of RB in Mexico.

Methods: A retrospective study was carried out on all RB cases treated in 16 institutions during the last six years. The variables analysed were age at diagnosis, sex, affected eyes, treatment modalities, and pathological staging. Overall survival was obtained.

Results: The authors analysed 500 cases; age range was 0–182 months. There were 364 unilateral cases (72.8%). Enucleation was performed in 84.9% of the patients. The St Jude’s staging was: 7.4% stage I, 52.8% stage II, 18.0% stage III, 11.4% stage IV, 7.2% not evaluated, and 3.2% missing data. Chemotherapy was used in 74.4% of the patients. Disease free survival was 89% at 73 months follow up.

Conclusions: The paper presents a great number of cases and pioneers multicentre studies in paediatric ophthalmology and oncology in this country. Given the great number of patients in advanced stages and the variability on treatment schemes, it is evident that it is mandatory to work in a cooperative group and develop a national early detection programme as well as a treatment protocol which include all specialists involved in the care of patients with RB.

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