Table 2
Retinoblastoma in children born through IVF
| Reference | Sex and age at diagnosis (months) | Eye | Cause of subfertility | DNA 13q14 analysis | Assisted reproductive technique |
|---|---|---|---|---|---|
| NR, not reported; AI, artificial insemination; ICSI, intracytoplasmic sperm injection. | |||||
| Current literature on retinoblastoma in children born through IVF includes three case reports that describe a total of six cases of retinoblastoma in these children. The characteristics of these patients and the patient discussed in this report are listed below. | |||||
| Anteby et al2 | NR, 30 | Unilateral | NR | NR | IVF with donor sperm |
| Moll et al3 | F, 38 | Both | Unexplained | Exon 8 mutated | IVF with 6 courses of clomid |
| Moll et al3 | M, 15 | Left | Maternal cause | Normal | IVF |
| Moll et al3 | F, 34 | Right | Unexplained | Normal | IVF |
| Moll et al3 | M, 8.5 | Both | Unexplained | Intron 3 mutated | IVF with 8 AI attempts |
| Moll et al3 | F, 32 | Left | Paternal cause | Normal | IVF with ICSI |
| This report | F, 16 | Right | Maternal cause | NR | IVF |
