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Br J Ophthalmol 88:1173-1179 doi:10.1136/bjo.2003.040949
  • Clinical science
    • Extended reports

Subthreshold micropulse diode laser treatment in diabetic macular oedema

Table 7

 Changes in retinal thickness

(A) Focal laser photocoagulation:
Diode laser (n = 6) Argon laser (n = 5)* p Value
ETDRS area A1
Baseline 275 (93) μm 325 (74) μm NS
3 months 250 (77) μm (−9%, −26 μm, −58 to +3 μm) 338 (90) μm (+4%, +13 μm, −9 to +44 μm) 0.02
6 months 256 (62) μm (−7%, −20 μm, −156 to +66 μm) 330 (100) μm (+2%, +5 μm, −4 to +79 μm) NS
ETDRS area A2–A9
Baseline 333 (68) μm 315 (41) μm NS
3 months 317 (65) μm (−5%, −16 μm, −44 to +14 μm) 317 (33) μm (+1%, +2 μm, −16 to +18 μm) NS
6 months 298 (58) μm (−10%, −34 μm, −137 to +14 μm) 305 (16) μm (−3%,−10 μm, −31 to +20 μm) NS
(B) Grid laser photocoagulation:
Diode laser (n = 6)* Argon laser (n = 6)* p Value
ETDRS area A1
Baseline 293 (43) μm 272 (51) μm NS
3 months 318 (74 μm (+8%, +25 μm, −16 to +73 μm) 308 (76 μm (+13%, +36 μm, −10 to +89 μm) NS
6 months 341 (81 μm (+16%, +48 μm, −22 to +104 μm) 290 (67 μm (+7%, +18 μm, −5 to +37 μm) NS
ETDRS area A2–A9
Baseline 309 (29) μm 305 (26) μm NS
3 months 306 (28) μm (−1%, −3 μm, −7 to +1 μm) 307 (38) μm (+1%, +2 μm, −11 to +31 μm) NS
6 months 295 (14) μm (−5%, −14 μm, −44 to +6 μm) 286 (27) μm (−6%, −19 μm, −45 to +8 μm) NS
(C) Focal and grid laser photocoagulation:
Initial diode laser (n = 12)* Initial argon laser (n = 11)* p Value
ETDRS area A1
Baseline 284 (70) μm 296 (65) μm NS
3 months 284 (81) μm (0%, 0 μm, −58 to +73 μm) 322 (80) μm (+9%, +26 μm, −10 to +89 μm) NS
6 months 294 (81 μm (+4%, +10 μm, −156 to +66 μm) 308 (80 μm (+4%, +12 μm, − 5 to +79 μm) NS
Diode laser (n = 12)* Argon laser (n = 11)* p Value
*n − 1 at 6 months observation. p Values comparing changes in percentage terms were calculated using the Mann-Witney test.
The mean retinal thickness in ETDRS area A1 and A2–A9 at baseline, 3, and 6 months after focal or grid photocoagulation with either diode or argon laser stated as mean (SD). Percentage change, change in μm, and range of change compared to baseline examination in parentheses (%, μm, range).
ETDRS area A2–A9
Baseline 321 (52) μm 310 (32) μm NS
3 months 311 (48) μm (−3%, −10 μm, −44 to +14 μm) 312 (34) μm (+1%, +2 μm, −16 to +31 μm) NS
6 months 297 (42) μm (−8%, −24 μm, −137 to +14 μm) 294 (24) μm (−5%, −15 μm, −45 to +20 μm) NS

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