rss
Br J Ophthalmol 2005;89:1542 doi:10.1136/bjo.2005.075689
  • Letter

Successful treatment of Wegener’s granulomatosis associated scleritis with rituximab

  1. C M G Cheung1,
  2. P I Murray1,
  3. C O S Savage2
  1. 1Ophthalmology, Division of Immunity and Infection, University of Birmingham, Birmingham, UK
  2. 2Nephrology, Division of Immunity and Infection, University of Birmingham, Birmingham, UK
  1. Correspondence to: Professor P I Murray Academic Unit of Ophthalmology, Birmingham and Midland Eye Centre, City Hospital, Dudley Road, Birmingham B18 7QU, UK; p.i.murraybham.ac.uk
  • Accepted 19 June 2005

Rituximab (Rituxan, Genentech, Inc, South San Francisco, CA, USA) is a new anti-CD20 B cell monoclonal antibody that has been used successfully to treat refractory cases of Wegener’s granulomatosis (WG).1–3 There has been no published report of its effect in Wegener’s associated eye disease. We describe the successful treatment of Wegener’s associated scleritis with rituximab.

Case report

A 21 year old man with WG, proved on renal biopsy and by anti-neutrophil cytoplasm antibody (ANCA) positivity 6 years earlier, presented with bilateral, painful, red eyes. On examination his visual acuities were 6/4 right eye and 6/5 left eye. Anterior segment examination showed subconjunctival haemorrhage, congested scleral vessels, scleral oedema, peripheral corneal infiltrates, and mild anterior …

[Full text of this article]

This Article

  1. Extract
  2. Full text
  3. PDF

Responses

  1. Submit a response
  2. No responses published

Register for free content

The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.