Table 3
The contribution of endothelium derived relaxing factors to bradykinin mediated relaxation of porcine ciliary arteries
| Protocol | Treatment | Emax (%) (n) | −logIC50 (n) |
|---|---|---|---|
| Values are expressed as mean (SEM) for arteries from (n) individuals. Data from vessels incubated with inhibitors were compared with the appropriate time dependent control using Student’s unpaired t test. Statistical comparison with the pre-incubation control was not made. *p<0.05 and **p<0.02 compared with appropriate control. Emax, maximum relaxation (%); L-NAME, l-NG-nitro-arginine methyl ester; Meclo, meclofenamic acid; ChTx, charybdotoxin; Apa, apamin. | |||
| (a) | Pre-incubation | 88..9 (3.2) (14) | 7.68 (0.19) (14) |
| Control (vehicle) | 82.6 (3.1) (10) | 7.14 (0.18) (10) | |
| L-NAME | 53.6 (12.9)** (7) | 7.58 (0.39) (7) | |
| (b) | Pre-incubation | 81.1 (7.1) (7) | 7.49 (0.16) (7) |
| Control (L-NAME) | 45..3 (10.3) (7) | 7.41 (0.54) (7) | |
| L-NAME/Meclo | 47.7 (12.8) (7) | 7.35 (0.28) (7) | |
| (c) | Pre-incubation | 81..3 (2.9) (7) | 7.12 (0.25) (7) |
| Control (L-NAME/Meclo) | 54..3 (11.7)* (7) | 6.25 (0.15) (7) | |
| L-NAME/Meclo/ChTx/Apa | 15..2 (4.2) (7) | 7.16 (0.39) (7) | |
